Stoichioproteomics (2005–2009)

Increasingly vast gene sequence databases constitute a tremendous repository of evolutionary information. Traditionally, analyses of protein evolution have explored the sources and consequences of changes in amino acid sequences, focusing on the relative contributions of particular amino acids to observed differences among proteins. This project attempts to determine if protein evolution is affected by element limitations that result in detectable usage biases based on amino acid element content. It is also developing a sophisticated bioinfomatics toolkit called “Genomics Resource Access for Stoichio-Proteomics” (GRASP) that will allow other researchers to query multiple existing databases to test related hypotheses involving element usage in proteomes.



NSF Bioinformatics Program